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Anticoagulant RNA-based therapies for SARS-CoV-2 related thrombosis

COVID-19 Research Area(s): Vaccines & Treatments

SARS-CoV-2 leads to hyper-coagulability of blood and deadly blood clots (thrombosis). The current anticoagulants may not be sufficient, due to the risk of bleeding from these drugs, and there is a need for alternative anticoagulants. In particular, agents that enhance clot degradation (fibrinolysis) without inducing bleeding are needed. We have been developing RNA-based agents that enhances fibrinolysis without leading to bleeding.

We have developed siRNA-based agents to modulate coagulation proteins and the proteins involved in clot degradation. Since there is a need for agents that safely enhance the degradation of blood clots, we are testing if several of these siRNA-based agents are effective.

Collaboration opportunities:
Clinical thrombosis, bleeding, hematology, transfusion.