COVID-19 Germline Analysis: Germline analysis of patients infected with the COVID-19 coronavirus

COVID-19 Research Area(s): Diagnostics, Genomics & Transmission Dynamics

1) Purpose. To generate complete genomic information for patients who have tested positive for a COVID-19 infection. This will allow the determination of any genetic determinants that influence the severity of the disease and the response to intervention.  2) Objectives. To create a database of genetic variants that can be correlated with features of coronavirus infection and patient phenotype information.  3) Research Method. Eligibility will be restricted to patients that have tested positive for COVID-19. Residual material remaining from COVID-19 testing will be used to isolate genomic DNA, which will then be subjected to whole genome sequencing. Where sufficient material exists, the sequence of the COVID-19 coronavirus may also be generated. There will be no blinding or randomization.  4) Statistical Analysis. It is likely, that data from British Columbia alone will be insufficient to robustly determine relevant genetic features (at least initially) and that insights will more likely be gained through data-sharing and interactions with international research consortia. For example, similar projects are being planned across Canada (Ontario and Quebec) and data would likely initially be shared with these studies.