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COVID-19 Inflammatory Blood Biomarkers for Clinical Management, Prognosis and Evaluation of Interventions

COVID-19 Research Area(s): Diagnostics, Genomics & Transmission Dynamics, Healthcare Delivery & Policy, Vaccines & Treatments

1) Determine the prevalence of a COVID-19 hyper-inflammatory "cytokine storm" phenotype in patients at Vancouver General Hospital 2) Determine any potential links between cytokine storm and ARDS in COVID-19 patients 3) Profile patients with mild and severe disease in an attempt to identify biomarkers that could be developed into a rapid test for triaging patients who require urgent care from those that will recover on their own 4) Elucidate the impact of genetic variation on clinical outcomes from COVID-19 5) Identify SARS-CoV-2 relevant RNAs 6) Determine the differences between the serum cytokine profile in COVID-19 patients with respiratory failure versus non-COVID respiratory failure ICU patients.